Researchers at Yale Cancer Center have identified a new subtype of triple negative breast cancer that shows significantly improved response to chemotherapy. Patients with the newly defined subtype — BRCA-deficient triple negative breast cancer — had significantly higher survival rates with chemotherapy.
The study was published on Dec. 13 in PLOS Medicine.
Triple negative breast cancer (TNBC) disproportionately affects young women of all races and women of African ancestry, contributing to health disparities. In an era when personalized cancer therapy has improved survival rates, patients with TNBC remain at considerably higher risk of relapse and death than patients with other types of breast cancer. This fact is due to the aggressive nature of TNBC and the lack of newer targeted therapies for the disease.