Public health researchers and practitioners often work to solve complex population and health issues, such as obesity and chronic disease, which are deeply embedded within the fabric of society. As such, the solutions often require intervention and engagement with key stakeholders and organizations across many levels, ranging from local entities (schools, churches, and work environments) to regional systems (health departments and hospital networks) to entire countries (national agencies). This multi-level, multi-participant view is at the heart of systems thinking, a process of understanding how parts influence one another within a whole. During December’s NCI Research to Reality (R2R) cyber-seminar, Dr. Allan Best will provide an overview of system thinking and practical tools to help navigate and analyze complex systems. Drs. Ross Brownson and Ken McLeroy will then provide real-world examples of how systems models can be applied in a variety of settings. Dr. Brownson will highlight the use of concept mapping and discuss the different levels that should be considered when implementing evidence-based programs within organizations or developing public health policies. Dr. McLeroy will focus on the use of social network analysis as a tool to analyze community capacity and ensure that organizations and communities are working together to develop, implement, evaluate, and sustain effective programs. Join us as we examine public health issues through a systems lens, and learn how your community and the programs, policies, and research you implement might benefit from this perspective. For more information about systems thinking, please visit the cyber-seminar to view some background materials.